Statin use is associated with fewer periodontal lesions: A retrospective study
نویسندگان
چکیده
BACKGROUND Inflammatory processes are considered to participate in the development of cardiovascular disease (CVD). Statins have been used successfully in the prevention and treatment of coronary heart disease. Chronic periodontitis has been suggested to contribute to CVD. The aim of this study was to examine the association of statin use and clinical markers of chronic periodontitis. METHODS Periodontal probing pocket depth (PPD) values were collected from dental records of 100 consecutive adult patients referred to a university dental clinic for treatment of advanced chronic periodontitis. A novel index, Periodontal Inflammatory Burden Index (PIBI), was derived from the PPD values to estimate systemic effects of periodontitis. RESULTS Periodontitis patients taking statins had a 37% lower number of pathological periodontal pockets than those without statin medication (P = 0.00043). PIBI, which combines and unifies the data on PPD, was 40% smaller in statin using patients than in patients without statin (P = 0.00069). PIBI of subjects on simvastatin and atorvastatin both differed significantly from patients without statin and were on the same level. The subjects' number of teeth had no effect on the results CONCLUSION Patients on statin medication exhibit fewer signs of periodontal inflammatory injury than subjects without the statin regimen. PIBI provides a tool for monitoring inflammatory load of chronic periodontitis. The apparent beneficial effects of statins may in part be mediated by their pleiotropic anti-inflammatory effect on periodontal tissue.
منابع مشابه
Author's response to reviews Title: Statin using periodontitis patients have markedly fewer periodontal lesions - a cross-sectional study Authors:
متن کامل
بررسی ارتباط بین ضخامت مخاط سینوس ماگزیلاری و با استفاده از periodontal bone loss Cone beam computed tomography
Introduction: Odontogenic infections are one of the common cause of maxillary sinusitis. This study aimed to evaluate the relationship between the teeth with periapical lesions or periodontal disease and sinus mucosal thickening using cone-beam computed tomography(CBCT). Methods: This was a retrospective and cross-sectional study. CBCT scans of 97 patients(188 sinuses) were evaluated retrospec...
متن کاملCholesterol, C-Reactive Protein, and Periodontitis: HMG-CoA-Reductase Inhibitors (Statins) as Effect Modifiers
Common risk factors of periodontitis and cardiovascular diseases fuel the debate on interrelationships between them. The aim is to prove whether statins may influence periodontal parameters by affecting either of these factors. Out of the 4,290 subjects of SHIP (Study of Health in Pomerania), we included subjects aged >30 years (219 with statins, 2937 without) and excluded edentulous. We determ...
متن کاملOral manifestations and its associated factors in Iranian Systemic lupus erythematosus (SLE) patients
Background and Objective: Due to the overall wide range of oral manifestations and the lack of comprehensive categorized information in Iran, this study was performed to investigate the prevalence of different oral manifestations and report their possible associated factors in patients with SLE. Materials and Methods: This cross-sectional study was performed on 96 SLE patients referred to two ...
متن کاملEffect of Areca Nut on Oral Health: A Review
Background and Aim: Oral health can be influenced by habitual areca nut chewing. The consumption of products containing areca nut, such as paan, gutkha, supari, etc., is common in Asian countries, such as India, Bangladesh, and Pakistan. In Iran, areca nut product consumption is common in the southeast of Iran, especially in Chabahar, Iranshahr, and Nikshahr cities, which are in proximity to th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- BMC Oral Health
دوره 8 شماره
صفحات -
تاریخ انتشار 2008